Clinical Guidelines for Managing Topotecan‐Related Hematologic Toxicity

Clinical Guidelines for Managing Topotecan-Related Hematologic Toxicity.

PURPOSE: Topotecan, a semisynthetic water-soluble camptothecin analog, was recently approved as a second-line treatment for women with ovarian cancer. In clinical trials, hematologic toxicity has been the predominant toxicity associated with its use. The purpose of this article is to provide guidelines on the clinical management of these toxicities. METHODS: The guidelines on the management of ...

Clinical Guidelines: Managing Common Coinfections and Comorbidities

Case-Based Reasoning for Managing Noncompliance with Clinical Guidelines

Despite the recognized advantages that can be obtained in clinical practice when following clinical guidelines (GL), situations of noncompliance with them may emerge. Keeping track of such deviations from the default GL execution, and documenting the physician’s motivations, would clearly be an added value. Moreover, repeated alterations of GL actions (or flow) may highlight the need for an ada...

Evolution of the HELEN Representation for Managing Clinical Practice Guidelines

Adaptation is a central process in the life cycle of clinical practice guidelines (CPGs), if a broad acceptance is to be achieved. Currently, there is no fully integrated solution for this process available. Due to the risk of introducing errors or compromising the evidence base, users and persons in charge often hesitate. To overcome these problems, we present a manageable pathway for the adap...

Case reports and clinical guidelines for managing radix entomolaris

Knowledge about the external and internal anatomy of the tooth is essential for successful dental practice. Anomalies in the tooth are often encountered which poses difficulties in dental treatments. As like any other tooth, mandibular first molars are also prone for anatomic malformations. One such anatomic variation is the presence of extra root distolingually. This distolingual root is calle...